Scientific News

Microbiome-based biomarkers: challenges on the path from research to clinical practice

Julie Rodriguez, researcher at Inserm (National Institute of Health and Medical Research, France) explored the main categories of microbiome-based biomarkers and their potential applications in clinical practice.

Mouse study links cognitive side effects of antipsychotics to gut microbes

Targeting the gut microbiota-ergothioneine pathway may offer a new way to prevent or treat cognitive side effects of antipsychotic drugs.

Gut microbes help deliver brain energy molecule, offering new path to treat depression

Supplementing creatine alongside specific gut bacteria such as Bifidobacterium could offer a treatment for depression by restoring brain energy metabolism.

From microbiome profiling to ibd diagnostics: Salient Bioscience advances standardized metagenomic testing

Marta Ciechonska of Salient Bioscience presented the company’s approach to developing standardized, reproducible microbiome tests based on shotgun metagenomic sequencing. 

High-fat diets may impair key gut immune cells, weakening intestinal defenses

Reducing dietary fat or controlling gut inflammation could help preserve immune cells and protect gut immunity, offering a strategy to prevent diet-related gut diseases.

Leaky gut may let some bacteria travel to the brain, mouse study shows

Maintaining a healthy gut barrier and microbiota, through diet or other interventions, could help prevent bacteria from reaching the brain, helping maintain neurological health.

Gut microbiota, immunity and diet: twenty years of research and the future of personalized nutrition

Francisco Guarner, from Centro Médico Teknon in Barcelona (Spain), discussed the most recent researches in the field of microbiome and nutrition.

Microbial metabolite shows promise against deadly infant disease

Boosting the gut metabolite indoleacrylic acid (IA), either directly or through the probiotic Bifidobacterium longum subsp. infantis, help protect the gut and prevent NEC.

Probiotics may help prevent bacterial vaginosis, small clinical study finds

Using probiotics such as LACTIN-V after antibiotic treatment could help prevent bacterial vaginosis, opening the way for tailored treatments based on individual microbiota profiles.

Gut microbes turn low-protein diets into fat-burning beige fat, mice study shows

The findings suggest that targeting specific gut microbes or their metabolites could boost fat-burning and metabolism in response to specific diets.

Gut bacteria cause memory loss in mice, but restoring gut-brain signals reverses it

Targeting gut bacteria, their metabolites, or gut-to-brain signaling could offer new strategies to prevent or treat age-related memory decline. 

Biotics in infant formula: promising evidence, but stronger clinical studies are needed

To better define the role of biotics in infant formula, future studies should be specifically designed to assess infection prevention, with adequate sample sizes, harmonised formulations and long-term follow-up.

Medicine is organised by body parts. Biology never got the memo.

The question for the next decade is whether healthcare institutions can reorganise around a biology they did not anticipate—one that is relational, systemic, and indifferent to the departmental boundaries medicine…

A model for electron transfer in the gut microbiome

B. luti plays a crucial role in maintaining gut homeostasis, microbial electron transfer and gut health by producing beneficial metabolites and regulating formate and hydrogen levels.

Gut bacterium triggers immune cells to kill colorectal tumors

Modulating the gut microbiota could be a new strategy to harness immune cells for treating colorectal cancer.

Gut bacteria may shape colon cell identity and protect against disease

Gut microbes, through metabolites such as niacin, shape the regional identity and protective functions of colon cells.

High sugar may promote severe fatty liver disease through gut bacteria

The findings suggest that L. salivarius can be a microbiota-based therapy for preventing severe fatty liver disease progression.

IBS Days: bridging science and clinical practice in irritable bowel syndrome

Giovanni Barbara (University of Bologna), Congress Chair, reflects on the key takeaways from the congress and shares his closing remarks.

Beyond antibiotic-associated diarrhea: probiotics, the gut microbiota, and the challenge of antimicrobial resistance

Francisco Guarner, from Centro Médico Teknon in Barcelona, discusses the role of probiotics in the prevention of antibiotic-associated diarrhea.

Microbiota differences might shape responses to viral infections

New study suggests that modifying the gut microbiota could shape baseline immune states to improve infection resistance and responses to vaccines and immunotherapies.

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