Scientific News

Specific gut microbe makes sepsis deadlier in mice

Sangeribacter muris KT1-3 made sepsis deadlier by amplifying inflammation driven by TLR4.

A microbiota-based strategy to prevent chemotherapy-induced gastrointestinal toxicity

Maria Rescigno presents a preclinical study investigating a non-absorbable antibiotic with eubiotic properties in a mouse model of gastrointestinal toxicity induced by the chemotherapeutic agent 5-fluorouracil (5-FU).

Health has a source. You were never told

If the soil microbiome is the first link in a chain that terminates in human health, then agricultural policy is health policy.

AI-based donor-matching tool may boost fecal transplant success rates

MOZAIC, an AI model designed to compare donor and recipients microbiotas, predicted the microbiota convergence after FMT with an accuracy of about 80%.

Bacterial metabolite may link irritable bowel syndrome to mood disorders

The findings highlight TnAse producing gut microbiota, indole, and AhR as promising therapeutic targets for IBS-associated affective disturbances.

Outer membrane vesicles: a new player in the microbiota–gut–brain axis

According to Stephen Michael Collins, McMaster University, these vesicles may represent not only a new component of the microbiota–gut–brain axis, but also a promising platform for future targeted drug, vaccine…

Vaginal microbiota compound linked to better development after C-section in mice

Restoring missing maternal microbes after C-section birth could be a new strategy to support early neurodevelopment.

Harnessing the plant microbiome to improve crop resilience and seed performance

The work of Angela Sessitsch, Head of Center at Austrian Institute of Technology, shows that environmental pressures such as drought can substantially reshape the plant microbiome.

Mouth bacteria may migrate to the gut and help drive gastric cancer

Microbes migrating from the mouth to the gut may play a role in gastric cancer and could become targets for diagnosis or treatment.

Gut bacterium may weaken treatment responses in esophageal cancer

Lactobacillus salivarius can make cancer immunotherapy less effective by producing indole-3-lactic acid (ILA), that weakens the body’s anti-tumor immune response.

C-section birth may shape babies’ genes, gut microbiota, and brain development

Early interventions targeting the infant gut microbiota, especially in babies born by C-section, may reduce the probability of neurodevelopmental conditions such as autism.

Breastfeeding may offset health impacts of poorer socioeconomic status in children

Supplementation with key beneficial bacteria, alongside efforts to reduce breastfeeding barriers, may offer scalable strategies to reduce socioeconomic health disparities.

Rapid microbiome testing: towards personalized skin and scalp care

David Suissa, CEO of BYOME LABS, discusses the growing interest in microbiome research, from the gut and vaginal ecosystems to the less explored skin, scalp and oral microbiomes.

Tumor microbiota differences between men and women offer clues to cancer outcomes

The presence of certain microbes was associated with major shifts in tumor gene activity and the immune environment around the cancer.

Microbiome-based biomarkers: challenges on the path from research to clinical practice

Julie Rodriguez, researcher at Inserm (National Institute of Health and Medical Research, France) explored the main categories of microbiome-based biomarkers and their potential applications in clinical practice.

Mouse study links cognitive side effects of antipsychotics to gut microbes

Targeting the gut microbiota-ergothioneine pathway may offer a new way to prevent or treat cognitive side effects of antipsychotic drugs.

Gut microbes help deliver brain energy molecule, offering new path to treat depression

Supplementing creatine alongside specific gut bacteria such as Bifidobacterium could offer a treatment for depression by restoring brain energy metabolism.

From microbiome profiling to ibd diagnostics: Salient Bioscience advances standardized metagenomic testing

Marta Ciechonska of Salient Bioscience presented the company’s approach to developing standardized, reproducible microbiome tests based on shotgun metagenomic sequencing. 

High-fat diets may impair key gut immune cells, weakening intestinal defenses

Reducing dietary fat or controlling gut inflammation could help preserve immune cells and protect gut immunity, offering a strategy to prevent diet-related gut diseases.

Leaky gut may let some bacteria travel to the brain, mouse study shows

Maintaining a healthy gut barrier and microbiota, through diet or other interventions, could help prevent bacteria from reaching the brain, helping maintain neurological health.

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