Oncology
Microbes migrating from the mouth to the gut may play a role in gastric cancer and could become targets for diagnosis or treatment.
Lactobacillus salivarius can make cancer immunotherapy less effective by producing indole-3-lactic acid (ILA), that weakens the body’s anti-tumor immune response.
The presence of certain microbes was associated with major shifts in tumor gene activity and the immune environment around the cancer.
Targeting specific bacterial strains, rather than overall gut diversity, can help develop effective microbiota therapies.
Bacterial extracellular vesicles released by L. salivarius activate immune cells, boosting the effectiveness of immunotherapy in stomach cancer.
Giulia Collattuzzo, University of Bologna, presents study findings showing an independent protective association between dietary fiber and gastric cancer risk, with consistent effects across sex, tumor location, and histological subtype.
Giuseppe Penna, from Humanitas University (Italy), presents the development of a novel postbiotic obtained from a single bacterial strain through an innovative fermentation process.
Modifying the microbiota through a fecal transplant can be safely combined with immunotherapy in people with kidney cancer.
Gut microbes can influence cancer outcomes by regulating nutrient availability and uptake in immune cells.
Researchers identified 36 bacterial species, particularly Hungatella hathewayi and Intestinimonas butyriciproducens, associated with colorectal cancer.
