Scientific News

Engineer single strain LBPs for robust tumor microenvironment disruption

Pedro Correa de Sampaio, Chief Executive Officer at Neobe Therapeutics, talks about the challenges to remove immunosuppressive constraints that prevent the infiltration of immune cells in a subset of cancers.

Developing psychobiotic LBPs tackling the gut-brain axis

Anna Chwalibóg, Chief Product Officer at Integral Solutions, talks about the opportunity to develop next-generation microbiome-based therapeutics for mental health and cognitive enhancement.

Antibiotics may alter gut microbes in ways that hinder cancer immunotherapy

The findings of a recent study suggest that targeting the interactions between MAdCAM-1 and specific receptors on the surface of immune cells may help to improve immunotherapy outcomes.

Preclinical data for MaaT03X, designed to improve response rate to immune checkpoint inhibitors in a solid tumor indication

Nathalie Corvaïa, Chief Scientific Officer at MaaT Pharma, gives an overview of preclinical and clinical results for MaaT013 and MaaT033.

Vaginal seeding may benefit babies born by C-section, small clinical study shows

The findings of a recent study suggest that vaginal seeding is safe and may normalize the gut microbiota in infants born by C-section.

Gut Microbiota: impact on intestinal diseases and beyond

Microbiomepost discussed with Herbert Tilg, Medizinische Universitat Innsbruck, Austria, about the importance of gut microbiome for intestinal and not intestinal health.

Validating the mechanism of action of BMC333 consortia through pre-clinical studies in IBD models

Osnat Tirosh, Head of Microbiome Research & Innovation at Biomica, talks about the validation of the mechanism of action of BMC333 consortia through pre-clinical studies in IBD models.

Key immune molecule helps keep commensal microbes in check

IgA can modulate the exposure and immune response to commensal microbes, and its levels determine the severity of immune dysregulation and clinical symptoms in people with IgA deficiency.

Commercial manufacture of microbial therapeutics at Sacco Systems: from microliters to tons

Christophe Roca, Head of Pilot Department at Sacco System, talks about development and GMP production of Live Biotherapeutics for all applications.

MBK-01, orally administered biologic medicine based in primary or recurrent Clostridiodes difficile infection

Juan Basterra, CEO at Mikrobiomik, talks about the interim results on MBK-01, the first intestinal microbiota-based biological drug in phase 3 for both primary episode and recurrence of Clostridioides dificile.

Nanomedicine improves symptoms of inflammatory bowel disease in mice

The findings of a new study suggest that the new nanomedicine approach can improve the delivery of TNF-α-siRNA in people with IBD.

Accelerated lung function decline in chronic obstructive pulmonary disease (COPD): a role for airway dysbiosis

Airway dysbiosis was associated with a lung function decline in COPD patients and it might contribute to this phenotype through metabolic interaction with host pathophysiological processes.

The importance of the mechanism of action in probiotics development

Nina Vinot (TargEDys International Sales Director) talks about a new promising way to isolate, study and bring to the market innovative probiotics.

Unlocking the potential of probiotics: genetically engineering Saccharomyces boulardii for effective obesity management

Karl Alex Hedin (Technical University of Denmark) talks about the potential role of genetically engineering Saccharomyces boulardii to produce an anti-obesity peptide.

Unveiling the link between gut microbiome and atrial fibrillation: insights from a large population study

A recent study poses the basis for the use of microbiome profile in AF risk prediction.

Probiotic-based hydrogel can treat yeast infection, support a healthy vaginal microbiota

The findings of a recent study suggest that combining Lactobacillus probiotics with nanozymes can help treat Candida vaginitis and help the growth of beneficial vaginal microbes.

Probionibacteria: from traditional cheese to next generation probiotics

Gwenael Jan (STLO - INRAE, France) talks about the growing interest and knowledge of Propionibacteria, a peculiar actinobacteria that has the potential to become a next generation probiotic.

The skin microbiome: challenges and opportunities in developing probiotics

Amine Zorgani (Microbiome Mavericks) talks about the importance of the skin microbiome in maintaining skin health and the need for continued research in this field.

Microbiota transplant after gastric bypass improves metabolism in mice

The findings of a recent study suggest that the gut microbiota contributes to improve metabolic health after gastric bypass surgery.

A cross-sectional study on the link between gut microbiota and inflammation in bipolar depression

Depressed BD patients present significant alterations in the taxonomic compositions of their gut microbiota, and this may be related to inflammatory pathways and depression severity.

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