Femme is a probiotic complex by SynBalance, specifically designed to support women’s intimate health. Clinically tested in 3 clinical trials, it confirmed the strains ability to colonize the vagina, as well as its effectiveness in supporting vaginal health against bacterial vaginosis and in post-menopausal women. In particular, Femme was able to reduce BV relapses and symptoms, and to lower inflammation while restoring vaginal microbiota in menopause.
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SynbÆctive® Femme
Discover characteristics, functionalities and scientific support of SynbÆctive® Femme.
Thearapeutical Area(s): Urogenital system, Women health
Age/Gender: Women
Dosage Form: sachets, capsule, sticks, tablets, triphase vials, bulk
CFU/Dose: 3 billion(s)
Scientific reference(s)
Mezzasalma, Valerio, et al. “”Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study.”” Archives of gynecology and obstetrics 295.1 (2017): 163-172.
Murina, Filippo, and Franco Vicariotto. “”Evaluation of an Orally Administered Multistrain Probiotic Supplement in Reducing Recurrences Rate of Bacterial Vaginosis: A Clinical and Microbiological Study.”” Advances in Infectious Diseases 9.3 (2019): 151-161.
Vicariotto, F.; Malfa, P.; Viciani, E.; Dell’Atti, F.; Squarzanti, D.F.; Marcante, A.; Castagnetti, A.; Ponchia, R.; Governini, L.; De Leo, V. Efficacy of Lactiplantibacillus plantarum PBS067, Bifidobacterium animalis subsp. lactis BL050, and Lacticaseibacillus rhamnosus LRH020 in the Amelioration of Vaginal Microbiota in Post-Menopausal Women: A Prospective Observational Clinical Trial. Nutrients 2024, 16, 402. https://doi.org/10.3390/nu16030402
L. plantarum PBS067, L. rhamnosus LRH020 and B. lactis BL050 (composing Femme) have been selected as the most performing strains in the prevention and support of women’s urogenital infections. We have deeply investigated mechanisms of action in several in-vitro and ex-vivo models against a wide range of urogenital pathogens as G. vaginalis, C. albicans, E. coli, N. gonorrhoeae, T. vaginalis, confirming a strong antimicrobial spectrum.
Presti, I., et al. “”Evaluation of the probiotic properties of new Lactobacillus and Bifidobacterium strains and their in vitro effect.”” Applied microbiology and biotechnology 99.13 (2015): 5613-5626.
Malfa, Patrizia, et al. “”Evaluation of Antimicrobial, Antiadhesive and Co-Aggregation Activity of a Multi-Strain Probiotic Composition against Different Urogenital Pathogens.”” International Journal of Molecular Sciences 24.2 (2023): 1323.
