Gastroenterology

Gut microbiota, intestinal barrier, and sepsis: from dysbiosis to probiotics—what preclinical evidence suggests

Francesco Franceschi from Policlinico Universitario A. Gemelli IRCCS (Roma) focuses on bacterial translocation across a compromised intestinal barrier as a plausible pathway contributing to sepsis.

Antibiotic-producing gut microbes might raise infection risk

Lantibiotic-producing gut bacteria can prolong gut imbalance and increase susceptibility to dangerous infections after antibiotics.

Toxin produced by gut bacteria may drive ulcerative colitis

MTB and aerolysin drive gut inflammation in ulcerative colitis.

Microbiome testing for post-infectious IBS: a pilot “microbe-informed” approach presented in Brussels

William Fusco, gastroenterologist at Policlinico Universitario Agostino Gemelli, highlighted a recently published pilot study on post-infectious irritable bowel syndrome (IBS) framed within microbial precision medicine and biomarker-driven care.

Gut bacteria from mothers with IBD may increase disease risk in children

Changes in gut bacteria raise a child’s chances of developing IBD later in life, offering clues to why the conditions sometimes runs in families.

From microbiota to prognosis: the gut–liver axis moves into clinical care

Francesca Ponziani from Gemelli University Hospital (Italy) highlights how the gut microbiota can become a clinical tool for identifying and stratifying patients, clarifying pathogenic mechanisms, and opening up new therapeutic…

Microbiota–immunity cross-talk: two sides of the same coin in colorectal cancer and IBD

Federica Facciotti, from University of Milano Bicocca, focuses on how the gut microbiota interacts with immune activation, shaping both chronic inflammatory intestinal disorders and oncology, particularly colorectal cancer. 

Gut microbes protect the liver by digesting fatty liver-causing sugar, fish study shows

Gut bacteria help protect the liver by breaking down sorbitol, a sugar made from glucose in the gut.

Some gut bacteria may reduce steroid hormone activity

A gut bacterium, Clostridium steroidoreducens, can chemically modify steroid hormones, including those used to treat IBD. 

Specific gut bacteria regulate intestinal motility by producing serotonin

L. mucosae and L. ruminis can produce serotonin in the gut, where it promotes nerve growth and regulates intestinal motility.

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