gut microbiota

Microbes fine-tune their protein production to make communities more efficient

Microbial communities may be engineered at the protein-expression level because bacteria adjust their protein production in response to specific neighbors.

Specific gut microbe makes sepsis deadlier in mice

Sangeribacter muris KT1-3 made sepsis deadlier by amplifying inflammation driven by TLR4.

A microbiota-based strategy to prevent chemotherapy-induced gastrointestinal toxicity

Maria Rescigno presents a preclinical study investigating a non-absorbable antibiotic with eubiotic properties in a mouse model of gastrointestinal toxicity induced by the chemotherapeutic agent 5-fluorouracil (5-FU).

AI-based donor-matching tool may boost fecal transplant success rates

MOZAIC, an AI model designed to compare donor and recipients microbiotas, predicted the microbiota convergence after FMT with an accuracy of about 80%.

Bacterial metabolite may link irritable bowel syndrome to mood disorders

The findings highlight TnAse producing gut microbiota, indole, and AhR as promising therapeutic targets for IBS-associated affective disturbances.

Outer membrane vesicles: a new player in the microbiota–gut–brain axis

According to Stephen Michael Collins, McMaster University, these vesicles may represent not only a new component of the microbiota–gut–brain axis, but also a promising platform for future targeted drug, vaccine…

Mouth bacteria may migrate to the gut and help drive gastric cancer

Microbes migrating from the mouth to the gut may play a role in gastric cancer and could become targets for diagnosis or treatment.

Gut bacterium may weaken treatment responses in esophageal cancer

Lactobacillus salivarius can make cancer immunotherapy less effective by producing indole-3-lactic acid (ILA), that weakens the body’s anti-tumor immune response.

C-section birth may shape babies’ genes, gut microbiota, and brain development

Early interventions targeting the infant gut microbiota, especially in babies born by C-section, may reduce the probability of neurodevelopmental conditions such as autism.

Breastfeeding may offset health impacts of poorer socioeconomic status in children

Supplementation with key beneficial bacteria, alongside efforts to reduce breastfeeding barriers, may offer scalable strategies to reduce socioeconomic health disparities.

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