SynBalance focuses its activity to discover and unlock the health-enhancing potentialities of the biotics family. With a vision to a sustainable future for all human kind, SynBalance mission consists into deliver science-based probiotic solutions, taking care of people health through the modulation of the microbiota.
An example of people care is represented by KEEPCALM, the probiotic complex composed by Limosilactobacillus reuteri PBS072 and Bifidobacterium breve BB077, a pool of proprietary strains designed for stress management.
According to the WHO stress is considered the “Health Epidemic of the 21st Century” and pandemic outbreak has further emphasized this condition. Moreover, the pursuit of happiness is having a renaissance moment, since consumers are seeking the silver linings to make them able to deal with life’s difficulties.
Likewise, in the latest year consumers’ online engagement on gut-brain has increased over 50%, highlighting their awareness about the gut-brain axis and probiotics support on mental wellness. With this perspective, the cognitive health market is projected to reach US$10.7 billion by 2025.
KeepCalm strains have been selected following an in-vitro screening on their ability in different models like neutrotransmitters production (GABA and serotonin) as well as the improvement of the activity of specific epigenetic enzymes.
To confirm their effects in humans, a proof-of-concept trial was carried out to evaluate stress-related parameters for 28 days of product intake in a group of 30 stressed students, which has open the possibility to enlarge the spectrum of action of KeepCalm in stress management.
Indeed, a double-blind crossover clinical trial was carried out to evaluate the probiotic complex ability on mood and sleep quality during Covid-19 pandemic. A total of 33 volunteers (healthy workers) were randomly assigned into two groups, with an inverted administration of KeepCalm (4B CFU/day) and placebo for 30 days each, with a 4-week intermediate wash-out. The efficacy on stress response, in terms of mood and sleep quality, were assessed using The Pittsburgh Sleep Quality Index (PSQI) and the Profile of Mood State (POMS) questionnaires. Results showed that both questionnaires reported a significant improvement of mood and sleep in the active group while the placebo perceived a worsening of their status and quality of sleep. Another clinical trial is about to be published highlighting the beneficial effect of KeepCalm on the management of post-partum period.
KeepCalm is an easy to formulate probiotic complex, thanks to its lower dosage of 4B/day (2B/strain), it can be declined in several delivery forms according to the target population is intended to address the finish product. Capsules and sticks for business people to students to support their cognitive function and manage stress situation even to older adults with easy-to-swallow solution to be improve their sleep quality.
“KeepCalm underlines the role of specific probiotic strain for stress relief, providing strong results against anxiety, low-mood and bad sleep quality. The main goal is not only to develop a probiotic supplement, but also to set a multidisciplinary revolution focusing on the awareness of taking care of mental health,” said Silvia Castegnaro, Product Manager.
More information on: https://www.synbalance.care/2023/02/13/keepcalm-managing-stress-during-the-covid-19-pandemic/
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