Oncology

Antibiotics may alter gut microbes in ways that hinder cancer immunotherapy

The findings of a recent study suggest that targeting the interactions between MAdCAM-1 and specific receptors on the surface of immune cells may help to improve immunotherapy outcomes.

Preclinical data for MaaT03X, designed to improve response rate to immune checkpoint inhibitors in a solid tumor indication

Nathalie Corvaïa, Chief Scientific Officer at MaaT Pharma, gives an overview of preclinical and clinical results for MaaT013 and MaaT033.

Researchers associate microbial signatures with two types of precancerous gut lesions

By providing insights into how the gut microbiota influences cancer susceptibility, the findings may help to develop new therapies or dietary interventions.

Gut microbes sway how people with lymphoma respond to immunotherapy

The findings of a recent study identified microbiota signatures that may allow clinicians to predict the outcomes of CAR-T immunotherapy.

Gut microbiome affects tumor regression of oncolytic adenovirus-treated melanoma

Microbiomepost discussed with Lorella Tripodi, University Federico II of Naples, about the research she is working with her colleagues.

How the sex hormone-gut microbiome axis influences tumor immunotherapy

Numerous evidences demonstrate the involvement of the sex hormone-gut microbiome axis in regulating the antitumor efficacy of ICIs.

Microbial metabolite may damage the DNA of gut stem cells

The findings of a recent study suggest that tilimycin-producing bacteria can cause genetic mutations in the colon and increase a person’s susceptibility to disease.

Immune cells may shuttle beneficial gut microbes to boost anticancer responses

The findings of a new study shed light on a general mechanism by which gut bacteria may influence anti-cancer immune responses.

Microbiota-derived metabolite may help combat pancreatic cancer

The findings of a new study suggest that the microbial metabolite 3-IAA could help to treat PDAC.

A Fusobacterium nucleatum vaccine to help protect against colorectal cancer?

Vaccines against F. nucleatum and other onco-microbes may help prevent diseases such as colorectal cancer.

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