Immunology

Key immune molecule helps keep commensal microbes in check

IgA can modulate the exposure and immune response to commensal microbes, and its levels determine the severity of immune dysregulation and clinical symptoms in people with IgA deficiency.

Nosocomial infection risks in critical illness: the microbiota-immune metasystem connection

An altered metasystem linking the gut microbiota and systemic immune response could lead to impaired host defense and increased vulnerability to hospital-acquired infections in cases of severe illness.

How some gut bacteria avoid immune surveillance

The immune system tolerates flagellins of commensal bacteria while mounting an immune response against flagellins produced by pathogens.

COVID-19 may disrupt gut microbiota to increase risk for other infections

Microbiota alterations in COVID-19 patients appeared to be associated with secondary infections of the blood by gut bacteria: four cases of positive blood cultures of Staphylococcus species were identified.

Some gut bacteria may trigger autoimmunity in rheumatoid arthritis

The findings of a recent study suggest that a specific strain of Subdoligranulum can drive the production of autoantibodies in rheumatoid arthritis.

How gut bacteria may evolve to become harmful

The findings of a new research show that gut bacteria can become harmful over time by gaining the ability to escape the intestine and persist in other organs where they…

IgA antibodies bind to specific gut bacteria in mice

The findings of a new research may inform strategies for treating intestinal diseases by targeting pathogens without killing beneficial gut bacteria.

Some gut bacteria produce key lipids involved in cell signaling

The findings of a recent study suggest that the production of inositol lipids is common in Bacteroidetes and other gut-associated bacteria, and it may be a means of cross-kingdom communication.

Gut microbes may contribute to damage the aging brain’s immune cells

The impact of age-induced microbiota alterations facilitates the accumulation of CML metabolite in the microglia of mice and humans.

Microbial metabolite may boost antitumor immunity in aggressive breast cancer

Researchers have found that a specific microbial metabolite may boost the efficacy of anticancer therapy in people with TNBC. The findings could inform the development of improved treatments for TNBC.

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