Wellderly is a probiotic complex by SynBalance, developed to support overall well-being in the elderly. In a randomized, double-blind, placebo-controlled clinical trial results showed enhanced anti-inflammatory and antioxidant responses, as well as shorter symptom duration. Additionally, genomic analysis confirmed a restoration of gut microbiota biodiversity, highlighting the product’s positive impact on immune and digestive health.
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SynbÆctive® Wellderly
Discover characteristics, functionalities and scientific support of SynbÆctive® Wellderly.
Thearapeutical Area(s): Healthy ageing
Age/Gender: Elderly
Dosage Form: sachets, capsule, sticks, tablets, triphase vials, bulk
CFU/Dose: 4 billion(s)
Scientific reference(s)
Sandionigi, Anna, et al. “Effectiveness of multistrain probiotic formulation on common infectious disease symptoms and gut microbiota modulation in flu-vaccinated healthy elderly subjects.” BioMed Research International 2022 (2022).
After a selection of the most performing strains according to different and complementary in-vitro models, L. plantarum – PBS067, B. lactis – BL050, B. infantis – BI221 and B. longum – BLG240 have been chosen to compose Wellderly.
The strains showed to modulate the inflammatory cascade (improvement of IL-4 and reduction of TNF-α), to increase cells anti-oxidant potential (FRAP test) enhancing also the activity of anti-oxidant enzymes (Catalase, Superoxide dismutase and Glutathione peroxidase). All these factors indeed, concur to regulate the low-grade chronic inflammation responsible for aging.
