Proteases and mucus degradation in Irritable Bowel Syndrome: emerging mechanisms and research priorities

Nathalie Vergnolle (Inserm, France) discussed the potential role of proteases in altering the intestinal mucus layer in irritable bowel syndrome (IBS).

Gut worms in mother mice linked to stronger antiviral defenses in pups

Microbiota-derived molecules such as IPA may offer a way to strengthen early-life immunity against respiratory viruses.

Autoimmune syndrome may be tied to changes in gut bacteria, fungi, and viruses

Monitoring the gut microbiota could in the future help understand, diagnose, or manage Sjögren syndrome.

Peppermint oil in IBS and functional dyspepsia: choosing treatment beyond efficacy

William Fusco, gastroenterologist at Gemelli University Hospital in Rome, discusses the role of peppermint oil in the management of disorders of gut–brain interaction.

Microbes fine-tune their protein production to make communities more efficient

Microbial communities may be engineered at the protein-expression level because bacteria adjust their protein production in response to specific neighbors.

Specific gut microbe makes sepsis deadlier in mice

Sangeribacter muris KT1-3 made sepsis deadlier by amplifying inflammation driven by TLR4.

A microbiota-based strategy to prevent chemotherapy-induced gastrointestinal toxicity

Maria Rescigno presents a preclinical study investigating a non-absorbable antibiotic with eubiotic properties in a mouse model of gastrointestinal toxicity induced by the chemotherapeutic agent 5-fluorouracil (5-FU).

Health has a source. You were never told

If the soil microbiome is the first link in a chain that terminates in human health, then agricultural policy is health policy.

AI-based donor-matching tool may boost fecal transplant success rates

MOZAIC, an AI model designed to compare donor and recipients microbiotas, predicted the microbiota convergence after FMT with an accuracy of about 80%.

Bacterial metabolite may link irritable bowel syndrome to mood disorders

The findings highlight TnAse producing gut microbiota, indole, and AhR as promising therapeutic targets for IBS-associated affective disturbances.

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