Gastroenterology

Microbiota–immunity cross-talk: two sides of the same coin in colorectal cancer and IBD

Federica Facciotti, from University of Milano Bicocca, focuses on how the gut microbiota interacts with immune activation, shaping both chronic inflammatory intestinal disorders and oncology, particularly colorectal cancer. 

Gut microbes protect the liver by digesting fatty liver-causing sugar, fish study shows

Gut bacteria help protect the liver by breaking down sorbitol, a sugar made from glucose in the gut.

Some gut bacteria may reduce steroid hormone activity

A gut bacterium, Clostridium steroidoreducens, can chemically modify steroid hormones, including those used to treat IBD. 

Specific gut bacteria regulate intestinal motility by producing serotonin

L. mucosae and L. ruminis can produce serotonin in the gut, where it promotes nerve growth and regulates intestinal motility.

Distinct gut microbes and metabolites underlie differences in irritable bowel syndrome 

Researchers have found that certain gut bacteria and their metabolites differ between IBS subtypes.

Microbiota-derived molecule regulates immune cell metabolism and gut inflammation

Controlling cadaverine levels and the gut bacteria that produce it could help regulate immune cell metabolism and inflammation.

Enteric pathogens as active drivers of dysbiosis: lessons from Bacillus cereus and experimental models of the gut microbiota

Emilia Ghelardi, Professor of Microbiology and Molecular Microbiology at the University of Pisa, explains how pathogens can actively disrupt the integrity of the commensal community.

Reinforcing the gut barrier: how probiotics support intestinal integrity and immune health

Arthur Ouwehand, Technical Fellow at IFF Finland, discusses the components and vulnerabilities of the gut barrier and reviews how probiotics and related dietary interventions can support its structure and function.

Faecalibacterium prausnitzii: a microbiome-based candidate for IBD, C. diff and cancer

Philippe Langella, Research director at INRAE, talks about how F. prausnitzii could be a beneficial commensal.

Standardizing evidence on probiotics in acute gastroenteritis: why guidelines diverge and clinicians are confused

Yvan Vandenplas, Head of the Pediatric Hospital at the University Hospital Brussels, uses the example of probiotics in acute gastroenteritis to highlight how heterogeneous methodologies in evidence synthesis can lead…

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