Gastroenterology

A microbiota-based strategy to prevent chemotherapy-induced gastrointestinal toxicity

Maria Rescigno presents a preclinical study investigating a non-absorbable antibiotic with eubiotic properties in a mouse model of gastrointestinal toxicity induced by the chemotherapeutic agent 5-fluorouracil (5-FU).

AI-based donor-matching tool may boost fecal transplant success rates

MOZAIC, an AI model designed to compare donor and recipients microbiotas, predicted the microbiota convergence after FMT with an accuracy of about 80%.

Mouth bacteria may migrate to the gut and help drive gastric cancer

Microbes migrating from the mouth to the gut may play a role in gastric cancer and could become targets for diagnosis or treatment.

Gut microbes turn low-protein diets into fat-burning beige fat, mice study shows

The findings suggest that targeting specific gut microbes or their metabolites could boost fat-burning and metabolism in response to specific diets.

A model for electron transfer in the gut microbiome

B. luti plays a crucial role in maintaining gut homeostasis, microbial electron transfer and gut health by producing beneficial metabolites and regulating formate and hydrogen levels.

Gut bacterium triggers immune cells to kill colorectal tumors

Modulating the gut microbiota could be a new strategy to harness immune cells for treating colorectal cancer.

Gut bacteria may shape colon cell identity and protect against disease

Gut microbes, through metabolites such as niacin, shape the regional identity and protective functions of colon cells.

High sugar may promote severe fatty liver disease through gut bacteria

The findings suggest that L. salivarius can be a microbiota-based therapy for preventing severe fatty liver disease progression.

Beyond antibiotic-associated diarrhea: probiotics, the gut microbiota, and the challenge of antimicrobial resistance

Francisco Guarner, from Centro Médico Teknon in Barcelona, discusses the role of probiotics in the prevention of antibiotic-associated diarrhea.

Mathematical model reveals how gut microbes shift in disease

Monitoring shifts in microbial interaction networks could help to detect and track gut-related conditions.

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