During the inauguration of Danone OneBiome Laboratory in Paris-Saclay, Microbiomepost.com sat down with Jan Knol, Senior Director Research & Innovation Specialised Nutrition Danone Nutricia Research Centers – Netherlands, to discuss about the present and the future of microbiome research.

This interview traces the journey of a scientist whose innate curiosity about how life works led to a career in microbiology and nutrition science, with a particular focus on the gut ecosystem. Beginning with the study of bacteria as simple biological systems, Jan Knol’s work evolved toward understanding the human gut microbiota and its role in health. A major milestone was the development of TIM, an artificial gut model created at TNO in the Netherlands, designed to replicate the complex processes of human digestion. This innovation has enabled detailed study of nutrient absorption, probiotic survival, and delivery of bioactive compounds. 

The discussion highlights the importance of early-life gut colonization, shaped by human milk, in programming immune, neural, and metabolic health, and underscores the gut’s central role as a hub for nutrient uptake, immune regulation, and gut–brain communication. The narrative also reflects on balancing short- and long-term scientific goals within multidisciplinary and international research teams, fostering both applied solutions and foundational discoveries. 

Looking ahead, the integration of data science, artificial intelligence, and digital twin models is identified as the next frontier for accelerating microbiome and nutrition research, transforming vast datasets into actionable insights for human health.