ProBeautyShield, a probiotic complex developed by SynBalance, is formulated to support overall skin health—particularly in individuals with atopic dermatitis and acne-prone skin—and to enhance skin appearance by reducing wrinkles in mature skin. Its effectiveness has been confirmed through five randomized, double-blind, placebo-controlled clinical trials. The first trial focused on atopic dermatitis, while two additional studies investigated acne in different populations (Caucasian and Chinese subjects), all showing significant improvements in skin condition. The remaining two trials targeted mature skin, demonstrating visible anti-aging benefits, including reduced wrinkles, enhanced radiance, and improved skin firmness and elasticity.
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SynbÆctive® ProBeautyShield
Discover characteristics, functionalities and scientific support of SynbÆctive® ProBeautyShield.
Thearapeutical Area(s): Skin health
Age/Gender: Adults
Dosage Form: sachets, capsule, sticks, tablets, triphase vials, bulk
CFU/Dose: 3 billion(s)
Scientific reference(s)
Michelotti, A., Cestone, E., De Ponti, I., Giardina, S., Pisati, M., Spartà, E., & Tursi, F. (2021). Efficacy of a probiotic supplement in patients with atopic dermatitis: a randomized, double-blind, placebo-controlled clinical trial. European Journal of Dermatology, 1(1)
Carlomagno F, Pesciaroli C, Cestone E, De Ponti I, Michelotti A, Tursi F. Clinical assessment on the effi cacy of a combined treatment targeting subjects with acne-prone skin. Our Dermatol Online. 2022;13(3):240-247.
Seo E, Song HH, Kim H, Kim BY, Park S, Suh HJ, Ahn Y. Oral Administration of Mixed Probiotics Improves Photoaging by Modulating the Cecal Microbiome and MAPK Pathway in UVB-Irradiated Hairless Mice. Mol Nutr Food Res. 2023 Apr 20:e2200841.
Shi Z, Malfa P, De Ponti I, Yu X, Lo Re M, Tursi F. Investigating the impact of oral probiotic supplementation for acne management: A randomized controlled trial. Our Dermatology Online. 2024;15(3).
Nobile, V., Hajat, C., Cestone, E., Cascella, F., & Santus, G. (2025). Skin Antiaging and Skin Health Benefits of Probiotic Intake Combined with Topical Ectoin and Sodium Hyaluronate: A Randomized, Double-Blind, Placebo-Controlled Trial. Cosmetics, 12(2), 34.
The most performing strains have been selected through several in-vitro models as the production of post-biotic metabolites & B-group vitamins, anti-inflammatory & anti-oxidant capacity and anti-microbial activity against skin pathogens (S. epidermidis, S. aureus, P. acnes), L. plantarum PBS067, L. reuteri PBS072 and L. rhamnosus LRH020.
Presti, I., et al. “”Evaluation of the probiotic properties of new Lactobacillus and Bifidobacterium strains and their in vitro effect.”” Applied microbiology and biotechnology 99.13 (2015): 5613-5626.
