EMA opens consultation on non-clinical requirements for microbiome-based medicines: what companies should do now

CHMP has announced the development of a dedicated reflection paper on the non-clinical development and evaluation of microbiome-based medicinal products (MMPs).

Dietary protein could influence cholera infection, mouse study shows

Dietary protein influences V. cholerae growth, metabolism, virulence, and competition with gut microbes.

Owning a dog may boost teens’ social skills and mental health through the microbiota

Some bacteria common in dog owners, particularly Streptococcus strains, were linked to fewer behavioral and attention problems.

Postbiotics: the story, the evidences, the ingredient

How postbiotics are reshaping dietary supplements and pharma: key insights from Humiome® Post LB.

Gut microbiota, intestinal barrier, and sepsis: from dysbiosis to probiotics—what preclinical evidence suggests

Francesco Franceschi from Policlinico Universitario A. Gemelli IRCCS (Roma) focuses on bacterial translocation across a compromised intestinal barrier as a plausible pathway contributing to sepsis.

Antibiotic-producing gut microbes might raise infection risk

Lantibiotic-producing gut bacteria can prolong gut imbalance and increase susceptibility to dangerous infections after antibiotics.

Toxin produced by gut bacteria may drive ulcerative colitis

MTB and aerolysin drive gut inflammation in ulcerative colitis.

Microbiome testing for post-infectious IBS: a pilot “microbe-informed” approach presented in Brussels

William Fusco, gastroenterologist at Policlinico Universitario Agostino Gemelli, highlighted a recently published pilot study on post-infectious irritable bowel syndrome (IBS) framed within microbial precision medicine and biomarker-driven care.

Nutrient competition may predict how gut microbes respond to drugs

Nutrient competition provides a predictive framework to anticipate and potentially mitigate drug side effects on the gut microbiota.

Gut bacteria and leucine may determine who benefits from exercise 

The interaction between gut microbes, the amino acid leucine and sIL-6R determines a person’s responsiveness to exercise.

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