Oncology

How the tumor microbiota may reduce the efficacy of cancer drugs

A recent study confirms that 5-FU exerts part of its anti-cancer effects through inhibiting the growth of F. nucleatum, the commensal associated with colorectal cancer progression.

DNA-damaging microbial metabolites found in people with inflammatory bowel disease

The findings of a recent study suggest that DNA damage-inducing microbial metabolites such as indolimines play a role in the development of colorectal cancer.

Tumor-microbiota interactions may help to identify new treatments for pancreatic cancer

The findings of a new research may help to develop improved diagnostic or treatment approaches for pancreatic cancer.

Studies reveal the fungal communities associated with tumors

New studies provide evidence that there may be fungi within tumors and could also help to diagnose certain types of cancer or predicting their course.

Microbial metabolite could boost efficacy of immunotherapy in pancreatic cancer

A gut microbial metabolite called trimethylamine N-oxide, or TMAO, could improve immunotherapy success in pancreatic cancer.

How Microbiotica Developed MB097, Live Bacterial Therapeutic that Could Boost Cancer Treatments

Ghaith Bakdash described how Microbiotica discovered a specific microbiome signature in patients responder to immune-oncology drugs such as anti-PD1 / PDL1 and developed a new bacterial consortium.

Bacteria in tumors may help cancer to metastasize

New research indicates that the tumor-resident microbiota can promote the formation of metastases as well as the survival of cancer cells during tumor progression.

Microbial metabolite may boost antitumor immunity in aggressive breast cancer

Researchers have found that a specific microbial metabolite may boost the efficacy of anticancer therapy in people with TNBC. The findings could inform the development of improved treatments for TNBC.

Lung microbiota may influence outcome of bone marrow transplant

New research investigates the role of lung microbiota in pediatric patients with lung infection or injury after bone marrow transplantation.

Specific gut bacteria may improve immunotherapy for melanoma

The findings could help to develop microbiota-based strategies to advance immunothery treatments for melanoma.

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