ibd

Microbiota–immunity cross-talk: two sides of the same coin in colorectal cancer and IBD

Federica Facciotti, from University of Milano Bicocca, focuses on how the gut microbiota interacts with immune activation, shaping both chronic inflammatory intestinal disorders and oncology, particularly colorectal cancer. 

Some gut bacteria may reduce steroid hormone activity

A gut bacterium, Clostridium steroidoreducens, can chemically modify steroid hormones, including those used to treat IBD. 

Microbiota-derived molecule regulates immune cell metabolism and gut inflammation

Controlling cadaverine levels and the gut bacteria that produce it could help regulate immune cell metabolism and inflammation.

Faecalibacterium prausnitzii: a microbiome-based candidate for IBD, C. diff and cancer

Philippe Langella, Research director at INRAE, talks about how F. prausnitzii could be a beneficial commensal.

Gut microbes help keep immune cells anchored in the intestine

Targeting the microbiota could be a new way to strengthen gut immunity and develop treatments for inflammatory bowel diseases such as Crohn’s disease.

How gut microbiota and genetic factors may drive inflammatory bowel disease

By revealing that OTUD3 limits microbiota-driven STING activation, the findings of a new study offer insights into the disease mechanisms of ulcerative colitis and may pave the way to new…

Identifying the next targets in IBD: pathobionts and their clinical impact

Recent studies have identified various bacterial and fungal pathobionts in patients with CD and UC.

Mice study shows how gut bacteria help train immune cells to prevent inflammation

STING activity is important for gut health and that targeting this molecule could offer new treatments for IBD.

Certain bile acids might help treat inflammatory bowel disease

TCA can help to manage IBD by supporting the gut barrier and influencing microbiota composition.

How exercise boosts gut health, helping prevent chronic diseases

Understanding the complex interactions between exercise, diet and gut health can help to develop approaches to influence the gut microbiota, boost immunity and prevent or manage gastrointestinal diseases.

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