DefensePlus is a probiotic complex by SynBalance, specifically designed to promote and support a healthy immune system. DefensePlus has been studied in two randomized double blind clinical trial focusing on the prevention from seasonal infections and the support of the immune system through the gut microbiota modulation in one case and on prevention from common colds in the other. Results demonstrated the ingredient’s strains ability to boost the immune system response and reduce incidence and symptoms of the studied infections.
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SynbÆctive® DefensePlus
Discover characteristics, functionalities and scientific support of SynbÆctive® DefensePlus.
Thearapeutical Area(s): Immune system
Age/Gender: Adults
Dosage Form: sachets, capsule, sticks, tablets, triphase vials, bulk
CFU/Dose: 3 billion(s)
Scientific reference(s)
De Giani A, Sandionigi A, Zampolli A, Michelotti A, Tursi F, Labra M, Di Gennaro P. 2022. “Effects of Inulin-Based Prebiotics Alone or in Combination with Probiotics on Human Gut Microbiota and Markers of Immune System: A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Subjects” Microorganisms 10, no. 6: 1256. https://www.mdpi.com/2076-2607/10/6/1256
Lungaro L, Malfa P, Manza F, et al. Clinical Efficacy of Probiotics for Relieving Cold Symptoms in Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Nutrients. 2025;17(9):1490.
The selection comes from a priori in-vitro screening on their ability in different in-vitro models identifying the mechanism of action involved in the immune system modulation (lowering TNF-α, upregulating IL-4, antioxidant activity) as well as the enhancement of antimicrobial peptides as BetaDefensin-2 belonging to the innate response.
