During the Microbiome Connect: USA 2022 congress, held last November in Boston, MicrobiomePost discussed with Leigh Frame, Director, Integrative Medicine, GW School of Medicine & Health Sciences in Washington about how to establish the feasibility of assessing microbiome attributes related to disparate dietary patterns using pooled samples and how to exploit metabolomic and genomic data to identify diet-specific signatures to develop predictive microbiome signatures.