One of the company’s core technologies is VIT® (vermicon identification technology), the further development and industry standardization of fluorescence in situ hybridization (FISH). The analysis is performed by fluorescence microscopy or flow cytometry (Flow VIT®). VIT® and Flow VIT® can specifically identify multiple bacterial populations and species in the same sample, distinguish between live and dead cells, and are cultivation-independent technologies. 

The combination of molecular methods with flow cytometry, which is achieved with the Flow VIT® technology, ensures rapid and accurate identification and enumeration of specific bacterial species. As a result, this technology is crucial for the quality control and efficacy of science-based next-generation probiotics.

Why choose vermicon?

• Rapid enumeration of multiple bacterial species in the same sample
• Spatial analysis, identification and visualization
• Viability, activity and safety analysis
• Validation of stability and viability throughout shelf life
• End products composition validation
• Microbial quality monitoring
• Contaminants control

How to implement? 

Using the VIT® and Flow VIT® technologies, vermicon AG performs a wide range of laboratory analyses under both GMP and non-GMP conditions. Additionally, the detection systems include standard and customized test kits and enable an easy-to-use in-house analysis of microorganisms.

Additionally, with over 25 years of experience in analyzing complex microbiological ecosystems, vermicon AG offers expert consulting services to help solve even the most challenging microbiological questions.

CosmosID also offers independently validated, industry-leading pipelines for processing metagenomic data, yielding multi-kingdom, strain-level resolution with leading sensitivity and precision. Results can be accessed via CosmosID-HUB, a user-friendly and interactive software for comparative analysis of microbiome data, complete with dynamic charts, visualizations, and statistics.

Our centre is home to a team of experts with in-depth knowledge, cutting-edge technology, and a passion for staying up-to-date with the latest scientific research.  

Our diagnostic analyses are aimed at identifying and understanding all types of microorganisms, from those that are essential for our well-being to those that are pathogenic. Moreover we analyse also human genomes with panels focused on cancer risks, neurodegeneration and immunity. With this knowledge, we can develop precision probiotics that specifically address the side effects of dysbiosis induced by pathologies or medications. Our probiotics are not limited to oral applications; we also deliver topical options.

At The BioArte, we are proud to be at the forefront of this exciting field, and we are committed to making a real difference in people’s lives. Join us on our mission to unlock the full potential of the microbiome and improve healthcare outcomes for everyone.

Wellmicro® Academy claims a solid support to the clinical board of professionals alongside with the scientific board.

Locations

• Legal head office: 1 Bruno Rizzi St. Bussolengo – Verona 37012 IT

• Headquarter: 30 Antonio Canova St. Bologna 40138 IT

Next-generation sequencing (NGS) technologies have been crucial in investigating and characterizing the human microbiome. However, the transformation of NGS data into actionable solutions is limited by challenges related to precision, turnaround time, cost per sample, and the need for complex bioinformatic pipelines. For this purpose, Bio-Me developed Precision Microbiome Profiling (PMP™) in collaboration with Thermo Fisher Scientific. PMP™ is a novel qPCR-based platform that allows accurate, quick (100-200 samples in 2 hours), reproducible, and cost-efficient large-scale microbiome profiling at the species/strain level. The output consists of quantitative and ready-to-use results, overcoming the need for bioinformatics data processing.

Bio-Me’s proprietary pipeline allows the development of specific qPCR assays for the microbial targets of interest. We currently offer four off-the-shelf profiling solutions:

1. Gut Microbiome Extensive Panel
2. IBD/IBS/Gut Health Screening Microbiome Panel
3. Colorectal Cancer Microbiome Panel
4. Vaginal Microbiome Panel

In addition, we offer a convenient gut microbiome sampling solution as a kit and extraction/purification of DNA.

Moreover, we are developing a dedicated skin microbiome panel covering major organisms important for skin health. We are also working on an immuno-oncology and an infant gut health panel. Thanks to the flexibility of the PMP™ platform, we can customize microbiome profiling panels according to our clients’ needs.

Bio-Me works with leading academic institutions worldwide and key opinion leaders in the microbiome field. We support pharma and biotech companies during the clinical development of microbiome-modifying drugs with our profiling solutions and our access to fecal samples and anonymized medical registries from more than 13 000 subjects (collaboration with HUNT4). In addition, Bio-Me participates in clinical trials for several disease areas, such as cancer immunotherapy, IBD, and colorectal cancer.

Key Features of PMP™

• End-to-end solution – From sample collection kit to microbiome profile results
• Short turnaround time – Results ready in 2-5 hours from sample arrival
• High throughput – Hundreds of samples analyzed simultaneously
• Ready-to-use results – No bioinformatics steps needed from your side for data processing
• Absolute quantification – The output is the number of genomes per ng of DNA
• High-level resolution – Species, subspecies, and strain level
• Highly reproducible and accurate

Products and offerings

Off-the-Shelf Offerings

Custom Solutions

Under Development

Our state-of-the-art clinic sites both in Ireland and the USA ensure we can offer multicentre multinational studies of all design types, across a broad and diverse array of health areas and product portfolios. Our highly qualified and dedicated team will help you manage all aspects of your clinical project and guide you through the entire process, while keeping you fully informed of progress. As we own and operate our own clinics all of our ICH-GCP certified team are on hand to ensure your data is of the very highest quality and integrity and in strict accordance with the protocol.

Some of our extensive clinical areas are healthy ageing, gastrointestinal function and disorder, physical activity and sports performance, nutritional investigations, stress and cognitive health and decline , cardiovascular health, metabolic syndrome, bone and joint health, immune function and microbiome dysbiosis of the gut, skin, vagina and oral cavity.

Many of the studies we work on have been and are investigations of microbiome therapeutics and other active ingredients in both healthy and patient populations. These include LBT’s, prebiotic fibres, probiotics strains and a host of other products.